Invitrogen™ STAT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534683

Catalog No. PIPA534683

Description

Recommended positive controls: Jurkat, Raji, K562, THP-1. Predicted reactivity: Rhesus Monkey (97%). IHC notes, Requires antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

Specifications

• Antigen: STAT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Stat2
• Gene Alias: 1110034C02Rik; 1600010G07Rik; acute phase response factor; acute-phase response factor; ADMIO; ADMIO1; Aprf; AW109958; AW496480; DNA-binding protein APRF; EGK_03803; HIES; IMD44; interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT; STAT 2; STAT113; STAT2; STAT-2; Stat3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20847, 6773
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P52630, Q9WVL2
• Gene Symbols: Stat2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 571 and 851 of STAT2 (Uniprot ID#P52630).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG