Invitrogen™ STAT2 Recombinant Rabbit Monoclonal Antibody (4A5P8)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542828

Catalog No. PIMA542828

Description

Immunogen sequence: KLPFWTWLDK ILELVHDHLK DLWNDGRIMG FVSRSQERRL LKKTMSGTFL LRFSESSEGG ITCSWVEHQD DDKVLIYSVQ PYTKEVLQSL PLTEIIRHYQ LLTEENIPEN PLRFLYPRIP RDEAFGCYYQ EKVNLQERRK YLKHRLIVVS NRQVDEL; Positive test controls include: A-549, U-937, Mouse brain, Rat testis. The target is usually found in the following locations: Cytoplasm, Nucleus.

STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

Specifications

• Antigen: STAT2
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P52630
• Gene Symbols: Stat2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 550-706 of human STAT2 (NP_0054101).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 4A5P8
• Conjugate: Unconjugated
• Gene: Stat2
• Gene Alias: 1110034C02Rik; 1600010G07Rik; acute phase response factor; acute-phase response factor; ADMIO; ADMIO1; Aprf; AW109958; AW496480; DNA-binding protein APRF; EGK_03803; HIES; IMD44; interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT; STAT 2; STAT113; STAT2; STAT-2; Stat3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 288774, 6773
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid