Invitrogen™ STAT5 alpha Recombinant Rabbit Monoclonal Antibody (BLR124H)

Catalog No.	Quantity
PIMA544437	100 μL
PIMA544438	10 μL

Catalog No. PIMA544437

Supplier: Invitrogen™ MA544437

Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

Specifications

• Antigen: STAT5 alpha
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: BLR124H
• Concentration: 100 μg/mL
• Conjugate: Unconjugated
• Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
• Gene: STAT5A
• Gene Accession No.: P42229, P42230
• Gene Alias: AA959963; mammary gland factor; mammary gland factor STAT5A; mammary gland factor; transcription factor; Mgf; Mpf; signal transducer and activator of transcription 5; signal transducer and activator of transcription 5a; signal transducer and activator of transcription factor 5A; STAT; STAT5; STAT5A; STAT5A, Mammary Gland Factor; STAT5A/MGF; STAT5B; STATA5
• Gene Symbols: STAT5A
• Host Species: Rabbit
• Immunogen: Peptide representing a region between residue 744 and the C-terminus (residue 794) of Human signal transducer and activator of transcription 5a.
• Purification Method: Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20850, 6776
• Target Species: Human, Mouse
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov