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Invitrogen™ STAT5 beta Recombinant Rabbit Monoclonal Antibody (6P5T0)
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Catalog No. PIMA542707
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PIMA542707 100 μL
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Catalog No. PIMA542707 Supplier Invitrogen™ Supplier No. MA542707
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: K-562, Mouse thymus, Mouse heart, Rat heart, HeLa. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: KQQAHDLLIN KPDGTFLLRF SDSEIGGITI AWKFDSQERM FWNLMPFTTR DFSIRSLADR LGDLNYLIYV FPDRPKDEVY SKYYTPVPCE SATAKAVDGY VKPQIKQVVP EFVNASADAG GGSATYMDQA PSPAVCPQAH YNMYPQNPDS VLDTDGDFDL EDTMDVARRV EELLGRPMDS QWIPHAQS.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STAT5 beta
Applications ELISA, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone 6P5T0
Concentration 0.53 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Stat5b
Gene Accession No. P42232, P51692, P52632
Gene Alias LOC101122961; mammary gland factor STAT5B; Signal transducer and activator of transcription 5a; signal transducer and activator of transcription 5B; STA5B; STAT; STAT5; STAT5B; transcription factor STAT5B
Gene Symbols Stat5b
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 600-787 of human STAT5B (P51692).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20851, 25126, 6777
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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