Invitrogen™ STAT5 beta Recombinant Rabbit Monoclonal Antibody (SD08-08)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542455

Catalog No. PIMA542455

Description

Positive Control: Hela cell lysate, RH-35 cell lysate, Hela, PC-3M, RH-35, human breast carcinoma tissue, mouse colon tissue, human spleen tissue, mouse testis tissue. Subcellular Location: Cytoplasm, Nucleus.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Specifications

• Antigen: STAT5 beta
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P42232, P51692, P52632
• Gene Symbols: Stat5b
• Immunogen: Recombinant protein within C-terminal mouse STAT5b.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: SD08-08
• Conjugate: Unconjugated
• Gene: Stat5b
• Gene Alias: LOC101122961; mammary gland factor STAT5B; Signal transducer and activator of transcription 5a; signal transducer and activator of transcription 5B; STA5B; STAT; STAT5; STAT5B; transcription factor STAT5B
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 20851, 25126, 6777
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid