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STAT5B (phospho S731) Rabbit anti-Human, Mouse, Rat, Polyclonal , Abnova™

Catalog No. 89956794 Shop All Abnova Corporation Products
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89-956-794 100 μL
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Catalog No. 89-956-794 Supplier Abnova Corporation Supplier No. PAB29588
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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human STAT5B.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq]

Specifications

Antigen STAT5B (phospho S731)
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of human STAT5B.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100) Western Blot (1:500-1:3000) The optimal working dilution should be determined by the end user.
Formulation In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene Alias STAT5
Gene Symbols STAT5B
Host Species Rabbit
Immunogen A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S731 of human STAT5B.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6777
Test Specificity STAT5B (phospho S731) polyclonal antibody detects endogenous levels of human STAT5B only when phosphorylated at serine 731.
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG
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