Invitrogen™ Staufen Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528479

Catalog No. PIPA528479

Description

Recommended positive controls: 293T, A431, H1299, HepG2, Molt-4, Raji, Neuro2A, 293 (input), Stau1-IP (GTX106566), Post-IP lysate from control rabbit IgG-IP, Post-IP lysate from Stau1-IP. Predicted reactivity: Mouse (95%), Rat (94%), Zebrafish (83%), Xenopus laevis (86%), Chicken (94%), Rhesus Monkey (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.

Specifications

• Antigen: Staufen
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Stau1
• Gene Alias: 5830401L18Rik; AW549911; C85792; Double-stranded RNA-binding protein Staufen homolog 1; PPP1R150; protein phosphatase 1, regulatory subunit 150; RP3-470L14.2; STAU; Stau1; staufen (RNA binding protein) homolog 1 (Drosophila); staufen double-stranded RNA binding protein 1; staufen RNA binding protein homolog 1; staufen, RNA binding protein, homolog 1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20853, 6780
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.93 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O95793, Q9Z108
• Gene Symbols: Stau1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 379 and 577 of Human Staufen.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG