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Tocris Bioscience™ Staurosporine
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Catalog No. 1285100U
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100 μg
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Catalog No. Quantity
12-851-00U 100 μg
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Catalog No. 12-851-00U Supplier Tocris Bioscience™ Supplier No. 1285/100U
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Description

Non-selective protein kinase inhibitor

Staurosporine is a broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C, p60v-src tyrosine protein kinase, protein kinase A, and CaM kinase II (IC50 values are 3nM, 6 nM, 7 nM and 20 nM, respectively). Staurosporine reduces nuclear myosin heavy chain 9 phosphorylation which inhibits gastric cancer cell progression in transgenic mouse models. Staurosporine inhibits cell viability and promotes apoptosis in oral and pancreatic cancer cells. Staurosporine also enhances efficiency of lentiviral transduction of human hematopoietic stem and progenitor cells by 2-fold, induces dopaminergic axonal outgrowth in vitro and triggers mitophagy. Staurosporine has high affinity (Kd = 100 nM) for the yjdF aptamer. The riboswitch function of yjdF motif RNAs is activated by Staurosporine and leads to robust reporter gene expressions in B. subtilis.

Staurosporine synthesized to Ancillary Material Grade is also available.

Chemical Identifiers

CAS 62996-74-1
Molecular Formula C28H26N4O3

Specifications

Quantity 100 μg
Formula Weight 466.54
Purity >98%
Molecular Weight (g/mol) 466.541
Chemical Name or Material Staurosporine

Safety and Handling

Recommended Storage Store at +4°C
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