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Staurosporine, Tocris Bioscience™

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Quantity:
100 μg
This item is not returnable. View return policy
62996-74-1
C28H26N4O3
466.541
HKSZLNNOFSGOKW-ZYSRIHRCSA-N
AM-2282, kinome_3629
49831000
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
This item is not returnable. View return policy
62996-74-1
C28H26N4O3
466.541
HKSZLNNOFSGOKW-ZYSRIHRCSA-N
AM-2282, kinome_3629
49831000
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Description

Non-selective protein kinase inhibitor

Staurosporine is a broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C, p60v-src tyrosine protein kinase, protein kinase A, and CaM kinase II (IC50 values are 3nM, 6 nM, 7 nM and 20 nM, respectively). Staurosporine reduces nuclear myosin heavy chain 9 phosphorylation which inhibits gastric cancer cell progression in transgenic mouse models. Staurosporine inhibits cell viability and promotes apoptosis in oral and pancreatic cancer cells. Staurosporine also enhances efficiency of lentiviral transduction of human hematopoietic stem and progenitor cells by 2-fold, induces dopaminergic axonal outgrowth in vitro and triggers mitophagy. Staurosporine has high affinity (Kd = 100 nM) for the yjdF aptamer. The riboswitch function of yjdF motif RNAs is activated by Staurosporine and leads to robust reporter gene expressions in B. subtilis.

Staurosporine synthesized to Ancillary Material Grade is also available.

Quantity 100 μg
Formula Weight 466.54
Percent Purity >98%
Chemical Name or Material Staurosporine

Safety and Handling

Recommended Storage : Store at +4°C