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Tocris Bioscience™ StemRegenin 1
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Catalog No. 708610
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70-861-0 10 mg
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Catalog No. 70-861-0 Supplier Tocris Bioscience™ Supplier No. 7086/10
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Description

Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.

Specifications

Chemical Name or Material 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9 H-purin-6-yl]amino]ethyl]phenol
CAS 1227633-49-9
Quantity 10 mg
Target Aryl Hydrocarbon Receptor Antagonists
Molecular Formula C24H23N5OS
Purity 0.98
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