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STF 118804

Catalog No. p-7116077
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25 mg
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Catalog No. Quantity
52-072-5 25 mg
52-075 5 mg
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Catalog No. 52-072-5 Supplier R&D Systems Supplier No. 5207/25
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Description

NAMPT Inhibitors

STF 118804 is a NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.

Specifications

Chemical Name or Material 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide
CAS 894187-61-2
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C25H23N3O4S
Formula Weight Observed MW: 461.53
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