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Invitrogen™ STIM1 Polyclonal Antibody
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Catalog No. PIPA580079
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100 μg
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Catalog No. Quantity
PIPA580079 100 μg
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Catalog No. PIPA580079 Supplier Invitrogen™ Supplier No. PA580079
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Jurakt whole cell, human K562 whole cell, human HepG2 whole cell, rat liver tissue, rat RH35 whole cell, mouse liver tissue. IHC: mouse intestine tissue, rat intestine tissue, human mammary cancer tissue. ICC/IF: A549 cell.

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STIM1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide
Gene STIM1
Gene Accession No. P70302, P84903, Q13586
Gene Alias D11S4896E; GOK; IMD10; RGD:1306831}; SIM; Stim1; stim1 {ECO:0000312; STIM1L; STRMK; Stromal interaction molecule 1; stromal interaction molecule 1 precursor; TAM; TAM1
Gene Symbols STIM1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human STIM1 (45-74aa AAEFCRIDKPLCHSEDEKLSFEAVRNIHKL).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20866, 361618, 6786
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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