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Invitrogen™ STIM1 Polyclonal Antibody
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Catalog No. PIPA582455
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100 μL
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PIPA582455 100 μL
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Catalog No. PIPA582455 Supplier Invitrogen™ Supplier No. PA582455
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VHPGSLVEKL PDSPALAKKA LLALNHGLDK AHSLMELSPS APPGGSPHLD SSRSHSPSSP DPDTPSPVGD SRALQASRNT RIPHLAGKKA VAEEDNGSIG EETDSSPGRK KFPLKIFK Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 91%.

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STIM1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene STIM1
Gene Accession No. P84903, Q13586
Gene Alias D11S4896E; GOK; IMD10; RGD:1306831}; SIM; Stim1; stim1 {ECO:0000312; STIM1L; STRMK; Stromal interaction molecule 1; stromal interaction molecule 1 precursor; TAM; TAM1
Gene Symbols STIM1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human STIM1. Recombinant protein control fragment (Product #RP-90418).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361618, 6786
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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