STIM1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-7271	150 μL

Catalog No. 50-172-7271 Supplier Proteintech Group Inc Supplier No. 115651AP150UL

Description

Rabbit Polyclonal Antibody

The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. 11565-1-AP is rabbit polyclonal antibody raised against the N-terminal of human STIM1.

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in maligcies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3′ end of this gene situated 1.6 kb from the 5′ end of the RRM1 gene.

Specifications

• Antigen: STIM1
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Polyclonal
• Concentration: 0.42 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: STIM1
• Gene Accession No.: P70302, Q13586
• Gene Alias: D11S4896E, GOK, STIM1, stromal interaction molecule 1
• Gene Symbols: STIM1
• Host Species: Rabbit
• Immunogen: STIM1 Fusion Protein Ag2140
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20866, 6786
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG