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STIM1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988621
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100 μL
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50-198-8621 100 μL
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Catalog No. 50-198-8621 Supplier Bioss Supplier No. BS8526R
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Rabbit Polyclonal Antibody

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.

Specifications

Antigen STIM1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene STIM1
Gene Accession No. Q13586
Gene Alias BOS_14934; D11S4896E; GOK; IMD10; RGD:1306831}; Sim; Stim1; stim1 {ECO:0000312; STIM1L; STRMK; Stromal interaction molecule 1; TAM; TAM1
Gene Symbols STIM1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human STIM1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6786
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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