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Invitrogen™ STING Monoclonal Antibody (OTI4E12)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA526032
Description
STING Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)
STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
Specifications
STING | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q86WV6 | |
TMEM173 | |
Full length human recombinant protein of TMEM173 produced in HEK293T cell. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG2a |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
OTI4E12 | |
Unconjugated | |
TMEM173 | |
2610307O08Rik; endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; hypothetical LOC533661; mediator of IRF3 activation; Mita; mitochondrial mediator of IRF3 activation; mitochondrial transmembrane protein 173; MMITA; Mpys; mSTING; NET23; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; poSTING; RGD1562552; rSTING; SAVI; Stimulator of interferon genes protein; stimulator of interferon response cGAMP interactor 1; STING; STING1; tm173; Tmem173; Transmembrane protein 173 | |
Mouse | |
Affinity Chromatography | |
RUO | |
340061 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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