MilliporeSigma™ STING, Mouse, Unlabeled, Clone: S17G2C4B7,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABF270

Catalog No. MABF270MI

Description

Stimulator of interferon genes protein (UniProt Q86WV6; also known as Endoplasmic reticulum interferon stimulator, ERIS, hMITA, hSTING, Mediator of IRF3 activation, Transmembrane protein 173) is encoded by the TMEM173 (also known as ERIS, MITA, MPYS, SAVI, STING) gene (Gene ID 340061) in human. STING is an adaptor protein activated by cytosolic dsDNA or cyclic dinucleotides and plays a critical role in initiating innate responses to infection by various pathogens, including Herpes simplex virus (HSV). Once activated, STING translocates to the endoplasmic reticulum and activates the TBK1/IRF3 pathway that in turn mediates the upregulation of interferon (IFN) β. In addition, the DNA sensor IFI16 is also known to function as a STING ligand and potentiates STING-dependent sensing of viral infection by presenting cellular viral DNA to STING. STING is a four transmembrane (a.a. 21-41, 47-67, 87-106, 116-136) protein with both its N- and C-terminal ends exposed intracellularly (a.a. 1-20 and 137-379).The C-terminal cytoplasmic tail contains the c-di-GMP-binding domain (CBD; a.a. 153-340) with two c-di-GMP-binding regions (a.a. 162-167 and 238-241).

Specifications

• Antigen: STING
• Classification: Monoclonal
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: Q86WV6
• Immunogen: His-tagged recombinant human STING C-terminal cytoplasmic domain fragment.
• Quantity: 100 μg
• Research Discipline: Inflammation & Immunology
• Gene ID (Entrez): NP_938023.1
• Target Species: Human
• Form: Purified

• Applications: Western Blot
• Clone: S17G2C4B7
• Conjugate: Unconjugated
• Gene: TMEM173, ERIS, MITA, MPYS, SAVI, STING
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone S17G2C4B7 recognizes an epitope in the C-terminal cytoplasmic domain of human and murine STING.
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Isotype: IgG1 κ

For Research Use Only. Not for use in diagnostic procedures.