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MilliporeSigma™ STING, Mouse, Unlabeled, Clone: S17G2C4B7,

Catalog No. MABF270MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABF270MI 100 μg Unconjugated
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Catalog No. MABF270MI Supplier MilliporeSigma™ Supplier No. MABF270
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Description

Mouse Monoclonal Antibody

Stimulator of interferon genes protein (UniProt Q86WV6; also known as Endoplasmic reticulum interferon stimulator, ERIS, hMITA, hSTING, Mediator of IRF3 activation, Transmembrane protein 173) is encoded by the TMEM173 (also known as ERIS, MITA, MPYS, SAVI, STING) gene (Gene ID 340061) in human. STING is an adaptor protein activated by cytosolic dsDNA or cyclic dinucleotides and plays a critical role in initiating innate responses to infection by various pathogens, including Herpes simplex virus (HSV). Once activated, STING translocates to the endoplasmic reticulum and activates the TBK1/IRF3 pathway that in turn mediates the upregulation of interferon (IFN) β. In addition, the DNA sensor IFI16 is also known to function as a STING ligand and potentiates STING-dependent sensing of viral infection by presenting cellular viral DNA to STING. STING is a four transmembrane (a.a. 21-41, 47-67, 87-106, 116-136) protein with both its N- and C-terminal ends exposed intracellularly (a.a. 1-20 and 137-379).The C-terminal cytoplasmic tail contains the c-di-GMP-binding domain (CBD; a.a. 153-340) with two c-di-GMP-binding regions (a.a. 162-167 and 238-241).
TRUSTED_SUSTAINABILITY

Specifications

Antigen STING
Applications Western Blot
Classification Monoclonal
Clone S17G2C4B7
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene TMEM173, ERIS, MITA, MPYS, SAVI, STING
Gene Accession No. Q86WV6
Host Species Mouse
Immunogen His-tagged recombinant human STING C-terminal cytoplasmic domain fragment.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation & Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_938023.1
Test Specificity Clone S17G2C4B7 recognizes an epitope in the C-terminal cytoplasmic domain of human and murine STING.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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