Invitrogen™ STK25 Polyclonal Antibody

Catalog No.	Quantity
PIPA561445	100 μL

Catalog No. PIPA561445 Supplier Invitrogen™ Supplier No. PA561445

Description

Rabbit Polyclonal Antibody

Immunogen sequence: PGISDKLMVH LVERVQRFSH NRNHLTSTR Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

STK25 (YSK1) is a serine/threonine kinase that belongs to the GCK family of kinases. It has been implicated as an upstream regulator of MAP kinase signaling pathways. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Specifications

• Antigen: STK25
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: STK25
• Gene Accession No.: O00506
• Gene Alias: 1500019J11Rik; AU018434; C86992; hypothetical protein; serine/threonine kinase 25; serine/threonine kinase 25 (STE20 homolog, yeast); serine/threonine kinase 25 (Ste20, yeast homolog); serine/threonine kinase 25 (yeast); serine/threonine-protein kinase 25; SOK1; SOK-1; Ste20, yeast homolog; ste20/oxidant stress response kinase 1; Ste20-like; ste20-like kinase; sterile 20/oxidant stress-response kinase 1; STK25; STK25 protein; Yeast Sps1/Ste20-related kinase 1; Ysk1
• Gene Symbols: STK25
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human STK25. Recombinant protein control fragment (Product #RP-100530).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10494
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG