Invitrogen™ STK38 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA576351

Catalog No. PIPA576351

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

STK38 (also known as NDR) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. STK38 is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of STK38 activity.

Specifications

• Antigen: STK38
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STK38
• Gene Alias: 5830476G13Rik; 9530097A09Rik; AA617404; NDR; Ndr Ser/Thr kinase-like protein; NDR1; NDR1 protein kinase; nuclear Dbf2-related kinase 1; serine/threonine kinase 38; serine/threonine-protein kinase 38; STK38
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 106504, 11329, 361813
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: TBS with 1% BSA, 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q15208, Q91VJ4
• Gene Symbols: STK38
• Immunogen: KLH conjugated synthetic peptide derived from human STK38: 31-130.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG