STK39 Mouse anti-Human, Clone: OTI4E3, liquid, TrueMAB™

Catalog No.	Quantity
50-167-7254	100 μg

Catalog No. 50-167-7254 Supplier OriGene Supplier No. TA600181

Description

Mouse Monoclonal Antibody

Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5′-upstream region ofPDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Specifications

• Antigen: STK39
• Applications: ELISA
• Classification: Monoclonal
• Clone: OTI4E3
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with <5% trehalose and 0.05% sodium azide
• Gene: STK39
• Gene Accession No.: Q9UEW8
• Gene Alias: DCHT, PASK, SPAK
• Gene Symbols: STK39
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human STK39 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 27347
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1