Invitrogen™ STMN4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101915

Catalog No. PIPA5101915

Description

Antibody detects endogenous levels of total STMN4.

RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.

Specifications

• Antigen: STMN4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STMN4
• Gene Alias: Lagl; R75359; Rb3; stathmin 4; stathmin-4; stathmin-like 4; stathmin-like protein B3; stathmin-like protein RB3; stathmin-like-protein RB3; Stmn4
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56471, 79423, 81551
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P63042, P63043, Q9H169
• Gene Symbols: STMN4
• Immunogen: A synthesized peptide derived from human STMN4(Accession Q9H169), corresponding to amino acid residues M50-A100.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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