Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. FEMA550560

Invitrogen™ STRAP Monoclonal Antibody (A7H11)
GREENER_CHOICE

Catalog No. FEMA550560
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
FEMA550560 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. FEMA550560 Supplier Invitrogen™ Supplier No. MA550560
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

Positive control: 293T cell lysate, Jurkat cell lysate, A549 cell lysate, MCF-7 cell lysate, SH-SY5Y cell lysate, human testis tissue. Predicted band size: 38 kDa Subcellular Location: Cytoplasm, Nucleus.

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STRAP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone A7H11
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Strap
Gene Accession No. Q9Y3F4
Gene Alias AW557906; C78091; C79202; MAP activator with WD repeats; MAWD; PT-WD; serine/threonine kinase receptor associated protein; Serine-threonine kinase receptor-associated protein; STRAP; UNR-interacting protein; UNRIP; WD-40 repeat protein PT-WD
Gene Symbols Strap
Host Species Mouse
Immunogen Recombinant protein within human STRAP aa 201-350/350.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11171
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.