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Invitrogen™ STRAP Polyclonal Antibody
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Catalog No. PIPA523165
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100 μg
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Catalog No. Quantity
PIPA523165 100 μg
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Catalog No. PIPA523165 Supplier Invitrogen™ Supplier No. PA523165
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Description

Rabbit Polyclonal Antibody

The amino acid sequence used as immunogen is 88% homologous in Xenopus and 83% homologous in Drosophila and Opossum.

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STRAP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% gelatin and 0.05% sodium azide
Gene Strap
Gene Accession No. Q5E959, Q9Y3F4, Q9Z1Z2
Gene Alias AW557906; C78091; C79202; MAP activator with WD repeats; MAWD; PT-WD; serine/threonine kinase receptor associated protein; Serine-threonine kinase receptor-associated protein; STRAP; UNR-interacting protein; UNRIP; WD-40 repeat protein PT-WD
Gene Symbols Strap
Host Species Rabbit
Immunogen A portion of amino acids 230-280 of human STRAP.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100067410, 11171, 20901, 486663, 510201
Target Species Human, Mouse, Canine, Monkey, Bovine, Horse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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