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Invitrogen™ STRAP Polyclonal Antibody
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Catalog No. PIPA563146
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100 μL
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PIPA563146 100 μL
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Catalog No. PIPA563146 Supplier Invitrogen™ Supplier No. PA563146
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FNMSVSSMEY IPEGEILVIT YGRSIAFHSA VSLDPIKSFE APATINSASL HPEKEFLVAG GEDFKLYKYD YNSGEELESY KGHFGP Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STRAP
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Strap
Gene Accession No. Q9Y3F4
Gene Alias AW557906; C78091; C79202; MAP activator with WD repeats; MAWD; PT-WD; serine/threonine kinase receptor associated protein; Serine-threonine kinase receptor-associated protein; STRAP; UNR-interacting protein; UNRIP; WD-40 repeat protein PT-WD
Gene Symbols Strap
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human STRAP. Recombinant protein control fragment (Product #RP-103219).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11171
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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