Invitrogen™ Substance P Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106886

Catalog No. PIPA5106886

Description

Antibody detects endogenous levels of total Substance P.

Substance P (SP) is currently thought to be one of the most important neurotransmitters and neurotransmitters in the brain. It is an undecapeptide belonging to the tachykinin family, which consists of excitatory neuropeptides synthesised in neuronal and glial cells of the human central and peripheral nervous system. Substance P, Neurokinin A, Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavage of the precursor Protachykinin-1. Substance P forms the major endogenous ligand for Neurokinin 1 Receptor. The pharmacology of Substance P has been associated with a number of neurological and psychiatric disorders, namely nociception, migraine, asthma, nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. It has also been linked to obesity.

Specifications

• Antigen: Substance P
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TAC1
• Gene Alias: 4930528L02Rik; C-terminal-flanking peptide; Hs.2563; MGC26719; neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; Neuropeptide gamma; neuropeptide K; NK1; NK-1; NK2; Nka; Nkna; NPK; PPT; Ppt5fl; PPTA; PPT-A; PPTA3; precursor 1; preprotachykinin; preprotachykinin A; protachykinin; protachykinin-1; RAT TAC; RATPPTA3; SP; substance K; Substance P; TAC; Tac1; TAC2; Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); tachykinin 1; tachykinin 2; tachykinin precursor 1; tachykinin, precursor 1; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21333, 24806, 6863
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P06767, P20366, P41539
• Gene Symbols: TAC1
• Immunogen: A synthesized peptide derived from human TAC1(Accession P20366), corresponding to amino acid residues L4-R54.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG