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Thermo Scientific Chemicals Sulindac Sulfide

Catalog No. AAJ62104MC
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Description

CAS: 32004-67-4 | C20H17FO2S, C20H17FO2S | 340.41 g/mol

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells, and reduces tumor burden in adenomatous polyposis patients. Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 32004-67-4
Molecular Formula C20H17FO2S, C20H17FO2S
Molecular Weight (g/mol) 340.41
MDL Number MFCD00869764
InChI Key LFWHFZJPXXOYNR-RQZCQDPDSA-N
IUPAC Name 2-[(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
SMILES CSC1=CC=C(\C=C2/C(C)=C(CC(O)=O)C3=CC(F)=CC=C23)C=C1

Specifications

Quantity 100 mg
Description Yellow
For Use With (Application) Active metabolite of sulindac; inhibits cyclooxygenase-1
Formula Weight 340.41g/mol
Melting Point 189°C to 191°C
Solubility Soluble in DMSO
Product Type Signal Transduction Reagent
Form Powder

Safety and Handling

EINECSNumber 250-892-2
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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