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Invitrogen™ SUMO-3 Recombinant Rabbit Monoclonal Antibody (1H9L17)

Catalog No. PI700186
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Catalog No. Quantity
PI700186 100 μg
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Catalog No. PI700186 Supplier Invitrogen™ Supplier No. 700186
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with chimpanzee and Rhesus monkey based on sequence homology. Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Small ubiquitin-related modifier proteins are members of the ubiquitin-like protein family. SUMO-3 regulates Amyloid beta generation and may be critical in the onset or progression of Alzheimer's disease. SUMO-2/3 forms poly-. SUMO-1, 2, and 3 proteins localize to the nuclear membrane, nuclear bodies, and cytoplasm, respectively. SUMOylation is essential for mammalian cell cycle regulation, SUMO-2/3 localizes to centromeres and condensed chromosomes where binds CENP-E.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SUMO-3
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 1H9L17
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene SUMO3
Gene Accession No. P55854, Q5XIF4, Q9Z172
Gene Alias 2810014B19Rik; D10Ertd345e; small ubiquitin like modifier 3; small ubiquitin-like modifier 3; small ubiquitin-related modifier 3; SMT3 (supressor of mif two, 3) homolog 1; SMT3 homolog 1; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 3; SMT3 suppressor of mif two 3 homolog 3 (yeast); Smt3A; Smt3B; SMT3H1; SUMO-2; Sumo3; SUMO-3; Ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B
Gene Symbols SUMO3
Host Species Rabbit
Immunogen A peptide corresponding to amino acids 91-103 of P55854.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20610, 499417, 6612
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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