Invitrogen™ SUMO1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517352

Catalog No. PIPA517352

Description

It is not recommended to aliquot this antibody.

SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment, via an isopeptide bond, to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved, for instance, in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. SUMO1 may also regulate a network of genes involved in palate development. Mutations in the gene can result in non-syndromic orofacial cleft 10.

Specifications

• Antigen: SUMO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SUMO1
• Gene Alias: CG4494-PA; DAP1; GAP modifying protein 1; GAP-modifying protein 1; GMP1; LD07775p; OFC10; OK/SW-cl.43; OTTHUMP00000202403; OTTHUMP00000202404; OTTHUMP00000202405; OTTHUMP00000202406; OTTHUMP00000202409; OTTHUMP00000202410; PIC1; SENP2; sentrin; Sentrin-1; small ubiquitin-like modifier 1; small ubiquitin-related modifier 1; small ubiquitin-related modifier-1; SMT3; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 1 (yeast); Smt3C; Smt3h3; SMTP3; Sumo1; SUMO-1; SUMO-1 related peptidase; Ubiquitin-homology domain protein PIC1; ubiquitin-like 1; ubiquitin-like 1 (sentrin); ubiquitin-like protein SMT3C; Ubiquitin-like protein UBL1; UBL1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22218, 301442, 7341
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 75 μg/mL
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P63165, P63166, Q5I0H3
• Gene Symbols: SUMO1
• Immunogen: Synthetic peptide corresponding to a sequence within human SUMO-1 that does not correspond to SUMO-2/3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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