Invitrogen™ SUMO4 Recombinant Rabbit Monoclonal Antibody (7X3V7)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535745

Catalog No. PIMA535745

Description

Immunogen sequence: MANEKPTEEV KTENNNHINL KVAGQDGSVV QFKIKRQTPL SKLMKAYCEP RGLSVKQIRF RFGGQPISGT DKPAQLEMED EDTIDVFQQP TGGVY.

SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.

Specifications

• Antigen: SUMO4
• Classification: Recombinant Monoclonal
• Concentration: 0.19 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6EEV6
• Gene Symbols: SUMO4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human SUMO4 (Q6EEV6).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 7X3V7
• Conjugate: Unconjugated
• Gene: SUMO4
• Gene Alias: dJ281H8.4; IDDM5; insulin-dependent diabetes mellitus 5; small ubiquitin-like modifier 4; small ubiquitin-like modifier 4 protein; Small ubiquitin-like protein 4; Small ubiquitin-related modifier 4; SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 2-like; SMT3 suppressor of mif two 3 homolog 4; SMT3H4; SUMO 4; Sumo2l; SUMO4; SUMO-4
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 387082, 682787
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid