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SUPT6H Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501558486
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50-155-8486 10 μL
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Catalog No. 50-155-8486 Supplier Bethyl Laboratories, Inc Supplier No. A300803AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

Specifications

Antigen SUPT6H
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene SUPT6H
Gene Accession No. Q7KZ85
Gene Alias KIAA0162, MGC87943, SPT6, SPT6H, emb-5, hSPT6; tat-CT2 protein; tat-cotransactivator 2 protein; transcription elongation factor SPT6
Gene Symbols SUPT6H
Host Species Rabbit
Immunogen Between 1553 and C-term
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6830
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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