Invitrogen™ SUPV3L1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597306

Catalog No. PIPA597306

Description

Immunogen sequence: APINKKQPFV CSSLLQFARQ YSRNEPLTFA WLRRYIKWPL LPPKNIKDLM DLEAVHDVLD LYLWLSYRFM DMFPDASLIR DLQKELDGII QDGVHNITKL IKMSETHKLL NLEGFPSGSQ SRLSGTLKSQ ARRTRGTKAL GSKATEPPSP DAGELSLASR LVQQGLLTPD MLKQLEKEWM TQQTEHNKEK TESGTHPKGT RRKKKEPDSD; Positive Samples: K-562, Raji, Jurkat, SW620, Mouse heart, Mouse kidney, Mouse liver; Cellular Location: Mitochondrion matrix, Nucleus, mitochondrion nucleoid.

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. [UniProt].

Specifications

• Antigen: SUPV3L1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SUPV3L1
• Gene Alias: 6330443E10Rik; ATP-dependent RNA helicase SUPV3L1, mitochondrial; Suppressor of var1 3-like protein 1; suppressor of var1, 3-like 1; suppressor of var1, 3-like 1 (S. cerevisiae); suppressor of var1, 3-like 1(SUV3); SUPV3L1; SUV3; Suv3 like RNA helicase; Suv3l1; SUV3-like helicase; SUV3-like protein 1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 294385, 338359, 6832
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.07 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q5EBA1, Q80YD1, Q8IYB8
• Gene Symbols: SUPV3L1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_0031622).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov