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Invitrogen™ SUR1 Monoclonal Antibody (N289/16), APC
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Catalog No. PIMA545558
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100 μg
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PIMA545558 100 μg
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Catalog No. PIMA545558 Supplier Invitrogen™ Supplier No. MA545558
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45558 was sufficient for detection of SUR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 160kDa. Does not cross-react with SUR2B. This antibody was formerly sold as clone S289-16.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SUR1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N289/16
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
Gene ABCC8
Gene Accession No. Q09428, Q09429
Gene Alias ABC36; ABCC8; AM60008PU-N; ATP binding cassette subfamily C member 8; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; D930031B21Rik; HHF1; HI; HRINS; LOW QUALITY PROTEIN: ATP-binding cassette sub-family C member 8; MRP8; PH SUR1; PHHI; sulfonylurea receptor; sulfonylurea receptor (hyperinsulinemia); sulfonylurea receptor 1; sulfonylurea receptor subunit 1; sulphonylurea receptor 1; SUR; SUR1; SUR1 protein; SUR1delta2; TNDM2
Gene Symbols ABCC8
Host Species Mouse
Immunogen Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100764394, 20927, 25559, 6833
Target Species Human, Mouse, Rat, Hamster
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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