Invitrogen™ SUV39H2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102008

Catalog No. PIPA5102008

Description

Antibody detects endogenous levels of total SUV39H2.

The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

Specifications

• Antigen: SUV39H2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SUV39H2
• Gene Alias: 4930507K23Rik; AA536750; D030054H19Rik; D2Ertd544e; FLJ23414; H3 K9 HMTase 2; H3-K9-HMTase 2; Histone H3-K9 methyltransferase 2; histone-lysine N-methyltransferase SUV39H2; KMT1; KMT1B; lysine N-methyltransferase 1B; RP11-2K17.2; Su; Su(var)3-9 homolog 2; suppressor of variegation 3-9 homolog 2; suppressor of variegation 3-9 homolog 2 (Drosophila); Suv39h histone methyltransferase; Suv39h2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64707, 79723
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9EQQ0, Q9H5I1
• Gene Symbols: SUV39H2
• Immunogen: A synthesized peptide derived from human SUV39H2(Accession Q9H5I1), corresponding to amino acid residues K117-S167.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG