SV40 Large T-Antigen Monoclonal Antibody (PAb101 (412)), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA512458

Catalog No. PIMA512458

Description

This antibody reacts with native and denatured large T-antigen. It does not react with the small T-antigen of SV40 or the large T-antigen of BKV, human papovavirus.

The SV40 T antigen is encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition, the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.

Specifications

• Antigen: SV40 Large T-Antigen
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
• Clone: PAb101 (412)
• Conjugate: Unconjugated
• Gene Alias: simian vacuolating virus 40; simian virus; Simian virus 40; sv40 large t antigen; sv40 virus large t antigen
• Immunogen: SV40 transformed mouse line B4
• Quantity: 500 μL
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Form: Liquid