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Invitrogen™ Syk Polyclonal Antibody
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Catalog No. PA186631
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100 μg
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Catalog No. Quantity
PA186631 100 μg
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Catalog No. PA186631 Supplier Invitrogen™ Supplier No. PA186631
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Description

Goat Polyclonal Antibody

Predicted to react with dog, mouse and rat based on sequence homology. In Western blot, this antibody detects a band at ~70 kDa in human bone marrow, lymph node and spleen lysates. Goat anti Syk antibody detects an epitope within the internal region of SYK, a approximately 70 kDa non-receptor protein tyrosine kinase whose role differs in haematopoietic and non haematopoietic stem cells.

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Syk
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Syk
Gene Accession No. P43405
Gene Alias DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
Gene Symbols Syk
Host Species Goat
Immunogen peptide with sequence C-KYLQQNRHVKDKN from the internal region of the SYK sequence (aa 458-470).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6850
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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