Invitrogen™ Syk Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA186631

Catalog No. PA186631

Description

Predicted to react with dog, mouse and rat based on sequence homology. In Western blot, this antibody detects a band at ~70 kDa in human bone marrow, lymph node and spleen lysates. Goat anti Syk antibody detects an epitope within the internal region of SYK, a approximately 70 kDa non-receptor protein tyrosine kinase whose role differs in haematopoietic and non haematopoietic stem cells.

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

Specifications

• Antigen: Syk
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Syk
• Gene Alias: DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
• Host Species: Goat
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6850
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P43405
• Gene Symbols: Syk
• Immunogen: peptide with sequence C-KYLQQNRHVKDKN from the internal region of the SYK sequence (aa 458-470).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG