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Invitrogen™ Syk Recombinant Rabbit Monoclonal Antibody (PSH0-76)
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Catalog No. FERMA549362
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FERMA549362 100 μL
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Catalog No. FERMA549362 Supplier Invitrogen™ Supplier No. MA549362
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Description

Rabbit Recombinant Monoclonal Antibody

Sequence Similarities: 100% Mouse. Tissue Specificity: Widely expressed in hematopoietic cells (at protein level) (PubMed:8163536). Expressed in neutrophils (at protein level) (PubMed:15123770). Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells (PubMed:8163536). Positive Control: Raji cell lysate, Daudi cell lysate, SW620 cell lysate, Ramos cell lysate. Subcellular Location: Cell membrane, Cytoplasm, cytosol. Predicted band size: 72 kDa.

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
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Specifications

Antigen Syk
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone PSH0-76
Concentration 0.963 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Syk
Gene Accession No. P43405
Gene Alias DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
Gene Symbols Syk
Host Species Rabbit
Immunogen Synthetic peptide within human aa 451-500 / 635.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6850
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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