Invitrogen™ Synapsin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ OPA104001

Catalog No. OPA104001

Description

In Western blot, this antibody detects an ~77 kDa and ~80 kDa protein representing synapsin I alpha and synapsin I beta respectively, in rat brain homogenate. Immunohistochemical staining of synapsin 1 alpha and 1 beta in human brain with OPA1-04001 yields a pattern consistent with cytoplasmic vesicle staining.

SYN1 (synapsin 1) is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins that associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains and are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. Synapsin 1 plays a role in regulation of axonogenesis and synaptogenesis. It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Specifications

• Antigen: Synapsin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SYN1
• Gene Alias: Brain protein 4.1; SYN1; Syn-1; SYN1a; SYN1b; Syn1-S; synapsin 1; synapsin I; synapsin Ia; synapsin Ib; synapsin-1; SYNI; truncated synapsin 1-S
• Host Species: Rabbit
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Bovine
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: Conc. Not Determined
• Formulation: whole serum with no preservative
• Gene Accession No.: O88935, P09951, P17599, P17600
• Gene Symbols: SYN1
• Immunogen: Native protein purified from bovine brain.
• Regulatory Status: RUO
• Gene ID (Entrez): 20964, 24949, 281510, 6853
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid