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Invitrogen™ Synaptophysin Monoclonal Antibody (SP11)

Catalog No. MA139558
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500 μL
1 mL
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MA139558 1 mL
PIMA516402 500 μL
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Catalog No. MA139558 Supplier Invitrogen™ Supplier No. MA139558
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Description

Rabbit Monoclonal Antibody

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is pancreas or neuroendocrine tumor.

Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Synaptophysin
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone SP11
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Tissue culture supernatant, TBS with 1% BSA and 0.1% sodium azide; pH 7.5
Gene Syp
Gene Accession No. P07825, P08247, Q62277
Gene Alias A230093K24Rik; AI848995; BM89 antigen; I79_012252; Major synaptic vesicle protein p38; MRX96; MRXSYP; p38; Syn; Synaptophysin; Syp; Syp I; Syp1
Gene Symbols Syp
Host Species Rabbit
Immunogen Synthetic peptide corresponding to C-terminus of human synaptophysin.
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20977, 24804, 6855
Target Species Human, Mouse, Rat
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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