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MilliporeSigma™ Synaptophysin, Mouse, Unlabeled, Clone: SY38,

Catalog No. MAB5258IMI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MAB5258IMI 100 μL Unconjugated
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Description

Mouse Monoclonal Antibody

Synaptophysin (UniProt P20488; also known as Major synaptic vesicle protein p38) is encoded by the SYP gene (Gene ID 280937) in bovine species. Synaptophysin is a 38kDa four-transmembrane glycoprotein on synaptic vesicle (SV) with both its N- and C-termini exposed cytoplasmically. Synaptophysin forms homomultimers in the SV membrane and is heavily phosphorylated on tyrosine residues in its C-terminal pentapeptide repeats. Synapthophysin is also known to interact with SV v-SNARE protein synaptobrevin II (sybII) when sybII is not engaged with other SNARE proteins, suggesting a role of synaptophysin in sybII retrieval during SV endocytosis. Consistently, synaptophysin-knockout neurons display reduced level of sybII at their nerve terminals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Synaptophysin
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone SY38
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene SYP
Gene Accession No. P20488
Host Species Mouse
Immunogen Presynaptic vesicles from bovine brain (Wiedenmann, B., and Franke, W.W. (1985). Cell. 41(3):1017-1028).
Purification Method Protein G Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_776388
Test Specificity Clone SY38 detects synaptophysin and stains synaptophysin-containing vesicles by targeting the flexible segment -SGGGG- in the center of the C-termimal pentapeptide repeats (Knaus, P., and Betz, H. (1990). FEBS Lett. 261(2):358-360).
Target Species Bovine
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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