Invitrogen™ Synaptotagmin 1/2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115993

Catalog No. PIPA5115993

Description

Antibody detects endogenous levels of total Synaptotagmin 1/2.

Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.

Specifications

• Antigen: Synaptotagmin 1/2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SYT1
• Gene Alias: AW124717; CMS7; FLJ42519; G630098F17Rik; Inositol polyphosphate-binding protein; IP4-binding protein; mKIAA4194; MYSPC; p65; R74640; RATSYNII; SVP65; synaptotagmin 1; synaptotagmin 2; synaptotagmin I; Synaptotagmin II; synaptotagmin-1; Synaptotagmin-2; SYNII; SYT; SYT1; SYT2; SytI; sytII
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 127833, 20979, 20980, 24805, 25716, 6857
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P21579, P21707, P29101, P46096, P46097, Q8N9I0
• Gene Symbols: SYT1, SYT2
• Immunogen: A synthesized peptide derived from human SYT1(Accession P21579), corresponding to amino acid residues Y283-K333.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov