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Invitrogen™ Synaptotagmin 1 Monoclonal Antibody (ASV30)
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Catalog No. MA125568
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100 μg
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Catalog No. Quantity
MA125568 100 μg
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Catalog No. MA125568 Supplier Invitrogen™ Supplier No. MA125568
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Description

Mouse Monoclonal Antibody

Recommended positive controls: Mouse or Rat brain tissue extract.. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin's Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Synaptotagmin 1
Applications Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone ASV30
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1mM PMSF, 50% glycerol and no preservative; pH 7.2
Gene Syt1
Gene Accession No. P21707, P46096, P48018
Gene Alias AW124717; DKFZp781D2042; FLJ42519; G630098F17Rik; P65; SV DKFZp781D2042; SV SYT; svp65; Syb1; synaptotagmin 1; synaptotagmin 1 L homeolog; synaptotagmin 2; synaptotagmin I; synaptotagmin I protein; synaptotagmin I variant b; Synaptotagmin II; Synaptotagmin XI; synaptotagmin-1; Synaptotagmin-2; SYT; Syt1; syt1.L; SYT2; SytI; SytII; XELAEV_18022019mg
Gene Symbols Syt1, syt1.L
Host Species Mouse
Immunogen Rat brain synaptic junctional protein complexes.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100350072, 20979, 25716, 281511, 447431
Target Species Mouse, Rat, Rabbit, Bovine, Frog, Shark
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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