SYNE1/CPG2/Nesprin 1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-156-9416	100 μL

Catalog No. 50-156-9416 Supplier Bethyl Laboratories, Inc Supplier No. A305058A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as ′dystrophins of the nucleus′ to maintain nuclear organization and structura integrity

Specifications

• Antigen: SYNE1/CPG2/Nesprin 1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: SYNE1
• Gene Accession No.: Q8NF91
• Gene Alias: RP1-130E4.2, 8B, ARCA1, C6orf98, CPG2, DKFZp781J13156, EDMD4, FLJ30878, FLJ41140, KIAA0796, KIAA1262, KIAA1756, MYNE1, SCAR8, dJ45H2.2
• Gene Symbols: SYNE1
• Host Species: Rabbit
• Immunogen: Between 4200 and 4250
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23345
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG