Invitrogen™ SYNE3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589105

Catalog No. PIPA589105

Description

Immunogen sequence: LRLLEESLLS LIRNWHLQRM EVDSGKKMVF TNNIPKSGFL INPMDPIPRH RRRANLLQEE EGSHEDFSQL LRNFGQWLQV ENSKLVRIIA MRTSTAEDLR TRKSKLQELE ARVPEGQHLF ENLLRLGPAR GTSDELEDLR YQWMLYKSKL KDSGHLLTQS SPGEPTGFQK TRRWRGLGSL F; Positive Samples: Jurkat, K-562, LO2, HepG2; Cellular Location: Nucleus envelope, Nucleus outer membrane, Rough endoplasmic reticulum, Single-pass type IV membrane protein.

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. [UniProt].

Specifications

• Antigen: SYNE3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SYNE3
• Gene Alias: C14orf139; C14orf49; KASH domain-containing protein 3; KASH3; LINC00341; Nesp3; nesprin-3; NET53; Nuclear envelope spectrin repeat protein 3; RGD1304563; spectrin repeat containing nuclear envelope family member 3; spectrin repeat containing, nuclear envelope family member 3; SYNE3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 161176, 212073
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.88 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q4FZC9, Q6ZMZ3
• Gene Symbols: SYNE3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 740-920 of human SYNE3 (NP_6898053).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG