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Invitrogen™ SynGAP Polyclonal Antibody
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Catalog No. PIPA558362
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100 μL
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PIPA558362 100 μL
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Catalog No. PIPA558362 Supplier Invitrogen™ Supplier No. PA558362
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LHLYRDSDKK RKKDKAGYVG LVTVPVATLA GRHFTEQWYP VTLPTGSGGS GGMGSGGGGG SGGGSGGKGK GGCPAVRLKA RYQ Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Synaptic Ras-GTPase activating protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SynGAP
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SYNGAP1
Gene Accession No. Q96PV0
Gene Alias DKFZp761G1421; Gm1963; KIAA1938; MRD5; Neuronal R; Neuronal RasGAP; OTTHUMP00000209046; p135 SynGAP; Ras GTPase-activating protein SynGAP; ras/Rap GTPase-activating protein SynGAP; RASA1; RASA5; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP; Syngap1
Gene Symbols SYNGAP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SynGAP. Recombinant protein control fragment (Product #RP-95040).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8831
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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