Invitrogen™ SynGAP Recombinant Rabbit Monoclonal Antibody (8M2S9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542710

Catalog No. PIMA542710

Description

Positive test controls include: Mouse brain, Rat brain. Immunogen sequence: SEKRLRQQQA EKDSQIKSII GRLMLVEEEL RRDHPAMAEP LPEPKKRLLD AQERQLPPLG PTNPRVTLAP PWNGLAPPAP PPPPRLQITE NGEFRNTADH.

Synaptic Ras-GTPase activating protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.

Specifications

• Antigen: SynGAP
• Classification: Recombinant Monoclonal
• Concentration: 0.7 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: F6SEU4, Q96PV0, Q9QUH6
• Gene Symbols: SYNGAP1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1244-1343 of human SynGAP (Q96PV0).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 8M2S9
• Conjugate: Unconjugated
• Gene: SYNGAP1
• Gene Alias: DKFZp761G1421; Gm1963; KIAA1938; MRD5; Neuronal R; Neuronal RasGAP; OTTHUMP00000209046; p135 SynGAP; Ras GTPase-activating protein SynGAP; ras/Rap GTPase-activating protein SynGAP; RASA1; RASA5; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP; Syngap1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 192117, 240057, 8831
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid