Invitrogen™ Synphilin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103172

Catalog No. PIPA5103172

Description

Antibody detects endogenous levels of total Synphilin-1.

Parkinson is the second most common neurodegenerative disease after Alzheimer's. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.

Specifications

• Antigen: Synphilin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNCAIP
• Gene Alias: 2810407O15Rik; 4933427B05Rik; Alpha-synuclein-interacting protein; BB104594; MGC39814; SNCAIP; Sph1; Synphilin 1; synphilin-1; synuclein alpha interacting protein; synuclein, alpha interacting protein; synuclein, alpha interacting protein (synphilin); SYPH1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 67847, 9627
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q99ME3, Q9Y6H5
• Gene Symbols: SNCAIP
• Immunogen: A synthesized peptide derived from human SNCAIP(Accession Q9Y6H5), corresponding to amino acid residues T725-S775.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov