Invitrogen™ Synphilin 1 Polyclonal Antibody

Catalog No.	Quantity
PIPA584665	100 μL

Catalog No. PIPA584665 Supplier Invitrogen™ Supplier No. PA584665

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RKASAVIHDQ HKLSTEETEI SPPLVKCGSA YEPENQSKDF LNKTFSDPHG RKVEKTTPDC QLRAFHLQSS AAESKPEEQV SGLNRTSSQG PEERSEYLK Highest antigen sequence indentity to the following orthologs: Rat - 64%, Mouse - 68%.

Parkinson is the second most common neurodegenerative disease after Alzheimer's. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.

Specifications

• Antigen: Synphilin 1
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: SNCAIP
• Gene Accession No.: Q9Y6H5
• Gene Alias: 2810407O15Rik; 4933427B05Rik; Alpha-synuclein-interacting protein; BB104594; MGC39814; SNCAIP; Sph1; Synphilin 1; synphilin-1; synuclein alpha interacting protein; synuclein, alpha interacting protein; synuclein, alpha interacting protein (synphilin); SYPH1
• Gene Symbols: SNCAIP
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human SNCAIP. Recombinant protein control fragment (Product #RP-107358).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9627
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG