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Invitrogen™ Synphilin 1 Polyclonal Antibody, Invitrogen™

Catalog No. FEPA5145488
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200 μL
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FEPA5145488 20 μL
FEPA5145487 200 μL
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Catalog No. FEPA5145488 Supplier Invitrogen™ Supplier No. PA5145488
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Description

Rabbit Polyclonal Antibody

Parkinson is the second most common neurodegenerative disease after Alzheimer's. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Synphilin 1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
Gene SNCAIP
Gene Accession No. Q99ME3
Gene Alias 2810407O15Rik; 4933427B05Rik; Alpha-synuclein-interacting protein; BB104594; MGC39814; SNCAIP; Sph1; Synphilin 1; synphilin-1; synuclein alpha interacting protein; synuclein, alpha interacting protein; synuclein, alpha interacting protein (synphilin); SYPH1
Gene Symbols SNCAIP
Host Species Rabbit
Immunogen Recombinant Rat SNCaIP1 protein, Pro766-Leu963 (Accession #D3ZWQ5).
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 307309, 67847
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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