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Invitrogen™ Syntaphilin Polyclonal Antibody
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Catalog No. PIPA520529
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100 μg
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Catalog No. Quantity
PIPA520529 100 μg
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Catalog No. PIPA520529 Supplier Invitrogen™ Supplier No. PA520529
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Description

Rabbit Polyclonal Antibody

Despite its predicted molecular weight, Syntaphilin often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is rat brain tissue lysate. PA5-20529 can be used with blocking peptide PEP-0649.

Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Syntaphilin
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SNPH
Gene Accession No. B5DF41, O15079, Q80U23
Gene Alias 6430515A01; AW045671; AW556958; AW743098; bA314N13.5; KIAA0374; mKIAA0374; Snph; Syntaphilin
Gene Symbols SNPH
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the center of human Syntaphilin.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 241727, 296267, 9751
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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