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Invitrogen™ Syntaphilin Polyclonal Antibody
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Catalog No. PIPA588474
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100 μL
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PIPA588474 100 μL
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Catalog No. PIPA588474 Supplier Invitrogen™ Supplier No. PA588474
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MEAGVQASCM QERAIQTDFV QYQPDLDTIL EKVTQAQVCG TDPESGDRCP ELDAHPSGPR DPNSAVVVTV GDELEAPEPI TRGPTPQRPG ANPNPGQSVS VVCPMEEEEE AAVAEKEPKS YWSRHY; Positive Samples: Mouse intestine, Rat brain, Rat testis; Cellular Location: Cell junction, Membrane, Single-pass membrane protein, synapse, synaptosome.

Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Syntaphilin
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.889 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene SNPH
Gene Accession No. B5DF41, Q80U23
Gene Alias 6430515A01; AW045671; AW556958; AW743098; bA314N13.5; KIAA0374; mKIAA0374; Snph; Syntaphilin
Gene Symbols SNPH
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 300-425 of human SNPH (NP_0555382).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 241727, 296267
Target Species Mouse, Rat, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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