Invitrogen™ Syntaphilin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583964

Catalog No. PIPA583964

Description

Immunogen sequence: FPASNTYEKL LCGMEAGVQA SCMQERAIQT DFVQYQPDLD TILEKVTQAQ VCGTDPESGD RCPELDAHPS GPRDPNSAVV V.

Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.

Specifications

• Antigen: Syntaphilin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNPH
• Gene Alias: 6430515A01; AW045671; AW556958; AW743098; bA314N13.5; KIAA0374; mKIAA0374; Snph; Syntaphilin
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9751
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O15079
• Gene Symbols: SNPH
• Immunogen: Recombinant protein corresponding to Human SNPH. Recombinant protein control fragment (Product #RP-99330).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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